主な論文リスト (過去5年間 2006-2011)
1. Naito K, et al: Two cases of acute promyelocytic leukemia complicated by torsade de pointes during arsenic trioxide therapy. Int J Hematol 83:318-23, 2006
2. Nakamura S, et al: Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells. Leuk Res 30:123-35, 2006
3. Ohnishi K, et al: Twenty-seven cases of drug-induced interstitial lung disease associated with imatinib mesylate. Leukemia 20:1162-4, 2006
4. Sahara N, et al: Clinicopathological and prognostic characteristics of CD33-positive multiple myeloma. Eur J Haematol, 2006;77:14-8.
5. Sahara N, et al: Role for interleukin-6 and insulin-like growth factor-I via PI3-K/Akt pathway in the proliferation of CD56- and CD56+ multiple myeloma cells. Exp Hematol 34:736-44, 2006
6. Yamazaki K, et al: Arrhythmogenic effects of arsenic trioxide in patients with acute promyelocytic leukemia and an electrophysiological study in isolated guinea pig papillary muscles. Circ J 70:1407-14, 2006
7. Fujisawa S, et al: Pharmacokinetics of arsenic species in Japanese patients with relapsed or refractory acute promyelocytic leukemia treated with arsenic trioxide. Cancer Chemother Pharmacol 59:485-93, 2007
8. Ohnishi K: PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia. Int J Clin Oncol 12:313-7, 2007
9. Yoshida H, et al: PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation. Mol Cell Biol 27:5819-34, 2007
10. Fujisawa S, et al. A variant transcript, e1a3, of the minor BCR-ABL fusion gene in acute lymphoblastic leukemia: case report and review of the literature. Int J Hematol. 2008;87:184-188.
11. Nakamura S, et al. KIS induces proliferation and the cell cycle progression through the phosphorylation of p27(Kip1) in leukemia cells. Leuk Res. 2008;32:1358-65
12. Sugimoto Y, et al. HOXA10 expression induced by Abl kinase inhibitors enhanced apoptosis through PI3K pathway in CML cells. Leuk Res. 2008;32:962-971.
13. Hirano I, et al. Depletion of pleckstrin homology domain leucine-rich repeat protein phosphatase 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms. J Biol Chem. 2009;284:22155-22165.
14. Nakamura S, et al. Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity. Invest New Drugs 2010;28:381-391.
15. Miyawaki S, et al: A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG AML201 Study. Blood 117:2366-72, 2011
16. Mizuta S, et al: Pre-transplant imatinib-based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR-ABL-positive acute lymphoblastic leukemia. Leukemia 25:41-7, 2011
17. Naito T, et al: CYP3A5*3 Affects Plasma Disposition of Noroxycodone and Dose Escalation in Cancer Patients Receiving Oxycodone. J Clin Pharmacol, 2011 [Epub ahead of print]
18. Nakamae H, et al: Nilotinib as frontline therapy for patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase: results from the Japanese subgroup of ENESTnd. Int J Hematol, 2011;93:624-32
19. Nakamura S, et al: Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression. Int J Cancer, 2011 [Epub ahead of print]
20. Ohtake S, et al: Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study. Blood 117:2358-65, 2011
21. Ono T, et al: BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay. Leuk Res 35:598-603, 2011
22. Yoshida M, et al: Analysis of bacteremia/fungemia and pneumonia accompanying acute myelogenous leukemia from 1987 to 2001 in the Japan Adult Leukemia Study Group. Int J Hematol 93:66-73, 2011
23. Ono T, et al: Impact of additional chromosomal abnormalities in patients with acute promyelocytic leukemia: 10-year results of the Japan Adult Leukemia Study Group APL97 study. Haematologica 96:174-6, 2011
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血液学は20世紀半ばまでは形態学の時代でした。この時代の醍醐味は、自分で骨髄穿刺をして染色し、自分で顕微鏡をみて診断をつけ、自分で治療をする事にありました。
